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Synthesis and antimicrobial evaluation of urea inclusion complexes

Ruchita Ohlan, Balasubramanian Narasimhan, Sucheta Ohlan Rakesh Narang and Vikramjeet Judge,

Org. Commun. (2008), 1:2; 24-32

Hindu College of Pharmacy, Sonepat, Haryana , India Faculty of Pharmaceutical Sciences, Maharshi Dayanand University , Rohtak – 124 001, India Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, India

Abstract: In the present study a series of urea inclusion complexes (1-30) were synthesized and evaluated for their in vitro antibacterial activity against Gram positive Staphylococcus aureus, Bacillus subtilis, Gram negative Escherichia coli and antifungal activity against Candida albicans and Aspergillus niger . The most of the synthesized complexes have shown moderate antimicrobial activity. The urea inclusion complexes of capric acid, pamoic acid and 3-hydroxybenzoic acid were found to be the most active ones.

Key words: Urea inclusion complexes; antibacterial activity; antifungal activity.