2.

Synthesis, spectral and antimicrobial activity of [3-(4-chloro-phenoxy)-2,4-diisopropyl)-2,3,4,5-tetrahydro-1H-3l5-benzo[e][1,3,2]diazaphosphepin-3-ylidene]-alkyl-amine (Staudinger reaction)

Ch. Mohan, A. Janardhan Rao, C. Naga Raju and R. Usha Nagalakshmi

Org. Commun. (2009), 2:4 ; 120-127

Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India

Department of Botany, Sri Venkateswara University, Tirupati-517 502, India

Abstract: 3-(4-chlorophenoxy)-2,4-diisopropyl-2,3,4,5-tetrahydro-1H-benzo[e][1,3,2]diaza-phosphepine was synthesized starting from  1,2-bis(bromomethyl)benzene by reacting with  2 equimolar isopropyl amine, one equimolar PBr3 and then one equimolar 4-chlorophenol, respectively. The Staudinger reaction of the diazaphphosphine with a series of  alkyl azides gave the corresponding iminophosphoranes. Antibacterial activities of the synthesized iminophosphoranes  were screened

Keywords: Iminophosphoranes; 1,2-bis(bromomethyl)benzene;  Isopropylamine; phosphorus tribromide; 4-chlorophenol; alkyl azides;  antimicrobial activity.