5.

Synthesis and antibacterial activity studies of novel 2-substituted-1,3,2-oxazaphosphole-2-oxide derivatives of (S)-(+)-prolinol

B. Satheesh Krishna, A. Janardhan Rao, K. Reddi Mohan Naidu, V. Koteswara Rao, and C. Naga Raju

Org. Commun. (2010), 3:4 ; xx-xx

Department of Chemistry, Sri Venkateswara University College of Sciences, Sri Venkateswara University, Tirupati-517 502, India

Abstract: The novel 2-substituted-1,3,2-oxazaphosphole-2-oxides of (S)-(+)-prolinol were synthesized by the cyclization of (S)-(+)-prolinol (3) with phosphorusoxychloride (4) followed by the treatment with various phenolic compounds, aminoacid esters and amine (6a-l) to obtain the title compounds (7a-l). Their structures are characterized by spectral, elemental analyses and evaluated their in vitro antibacterial activity against two gram positive and two gram negative bacteria. Three compounds exhibited very significant anti bacterial activity when compared with that of Ciprofloxacin.

Keywords: L–Prolinol; phosphorus oxychloride; 1,3,2-oxazaposphole-2-oxides; antibacterial activity.