2.

Synthesis and evaluation of a series of 1-substituted tetrazole derivatives as antimicrobial agents

Dhayanithi Varadaraji, Syed S. Suban, Venkat R. Ramasamy, Kumaran Kubendiran, Jai Sankar K. G. Raguraman, Suchetha K. Nalilu and Hari N. Pati

Org. Commun. (2010), 3:3 ; 45-56

P.G. and Research Department of Chemistry, Islamiah College, Vaniyambadi 632 752, India;

Chemistry Division, School of Science and Humanities, VIT University, Vellore 632 014, India;

Department of Biochemistry, K.S. Hegde Medical Academy, Mangalore 574 162, India;

Department of Chemistry, Sambalpur University, Jyoti Vihar 768 019, India.

Abstract: The screening of compounds is an alternative approach to high-throughput screening for identification of leads for therapeutic targets. A series of novel 1-substituted tetrazole derivatives were synthesized and evaluated for their antibacterial and antifungal activity. All the derivatives were efficiently synthesized by four steps process . In this study, thiazole attached tetrazole derivatives were most active than the piperazine attached tetrazole derivatives. The structure of the newly synthesized compounds was elucidated by their 1H NMR, 13C NMR, LC-MS/MS, IR spectral data and elemental analysis. The detailed synthesis, spectroscopic and biological evaluation data are reported .

Keywords: tetrazole; piperazine; thiazole; antibacterial; antifungal