Synthesis and biological activity of 2-oxo-azetidine derivatives of phenothiazine
Sharma Ritu, Samadhiya Pushkal, Srivastava S. D. and Srivastava S. K.
Org. Commun. (2011), 4:2 ; 42-51
Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour University, Sagar, M.P. India 470003
Abstract: We have synthesized of N-[2-(10H-phenothiazinyl)ethyl]-4-(phenyl)-3-chloro-2-oxo-1-iminoazetidine 4(a-m). The structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and FAB-Mass and chemical methods. All synthesized compounds were evaluated for their antibacterial, antifungal and antitubercular activity which displayed acceptable results.
Keywords: Synthesis;biological activity; 2-azetidinone, phenothiazine. |