One pot synthesis of 2-hydroxy pyrrolidine derivatives
Putta. P. Varma, Kittappa. M. Mahadevan, Abdul Khader and Vijaykumar Hulikal
Department of Post Graduate Studies and Research in Industrial Chemistry,
Kuvempu University, Shankaraghatta, Karnataka, 577451, India.
Department of Post Graduate Studies and Research in Chemistry, School of Chemical Science, Kuvempu University, Shankaraghatta, Karnataka, 577451, India.
Bioorganics and Applied Materials Pvt. Ltd., Bangalore, India
Abstract: One pot reaction of various 2-amino-thiadiazoles or thiazoles and 2,3- dihydrofuran under mild condition in presence of CeCl 3.7H 2O as catalyst transformed the amino group of 2-amino-thiadiazoles or thiazoles into a medicinally important 2-hydroxy pyrrolidine ring system in good to excellent yields. The generality of the reaction was sufficiently investigated and demonstrated. The new reaction path way for this conversion was established by spectroscopic and analytical methods.
Keywords: 2-Hydroxypyrrolidine; cerium(III)chloride heptahydrate; 2,3-dihydrofuran |