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Facile synthesis of some novel 2-substituted-4,6-diarylpyrimidines using 4 ' -hydroxy-3 ' ,5 ' -dinitrochalcones and S-benzylthiouronium chloride

K. L. Ameta, Biresh Kumar, Nitu S. Rathore and B. L. Verma

Department of Chemistry, Faculty of Arts, Science and Commerce, Mody Institute of Technology & Science, Lakshmangarh - 332311, Rajasthan, India

Department of Chemistry, M. L. Sukhadia University, Udaipur-313001, Rajasthan, India

Abstract: Various 4'-hydroxy-3',5'-dinitro substituted chalcones 1 and S-benzylthiouronium chloride (SBT) 2 in the presence of DMF-organic bases (morpholine/ pyrrolidine/ piperidine) gave 4,6-diaryl-2-(4-morpholinyl / 1-pyrrolidinyl /1-piperidinyl)- pyrimidines 4, 5 and 6 in a facile one-pot conversion. In an another attempt reactants 1 and 2 yielded intermediate 2-benzylthiopyrimidines 3, in presence of DMF, which on treatment with heterocyclic secondary amines gave products 4, 5 and 6 in an alternate two-step process.

Keywords: Chalcone; S-benzylthiouronium chloride; heterocyclic secondary amines.