18.

KHSO 4-SiO 2 catalyzed facile synthesis of bis(indolyl)methanes

K. Reddi Mohan Naidu, Shaik Ibrahim Khalivulla, P. Chenna Rohini Kumar and Ola Lasekan

Department of Food Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, UCSI University, No.1, JalanMeneraGading, 56000 Cheras, Kuala Lumpur, Malaysia.

Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India.

Abstract: This work presents a highly efficient and simple method for the synthesis of bis(indolyl)methanes, catalyzed by KHSO 4-SiO 2 with excellent yields. Various substituted aldehydes with indole under this reaction condition is elucidated. This method is an environmentally benign, efficient reaction, requires shorter reaction time and simple experimental and workup procedures.

Keywords: KHSO 4-SiO 2; aldehydes; indole; bisindolylmethanes; solvent-free reaction.