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p -Dimethylaminopyridine (DMAP): A highly efficient catalyst for one pot, solvent free synthesis of substituted 2-amino-2-chromenes under microwave irradiation

Kamlesh R. Desale, Kamalakar P. Nandre and Shamkant L. Patil

School of Chemical Sciences, North Maharashtra University, Umavi Nagar, Post Box 80, Jalgaon-425 001, (M.S.), India

Abstract: A highly efficient, green and expeditious method is described for the synthesis of substituted 2-amino-2-chromenes employing one pot three component condensation of aromatic aldehydes, malononitrile and activated phenol in presence of p-dimethylaminopyridine (10 mol %) as a catalyst under microwave irradiation. The present method is operationally simple and offers many advantages such as high yield, short reaction time and simple workup.

Keywords: 2-amino-2-chromenes; multicomponent; p-dimethylaminopyridine; microwave irradiation.