4.

L-proline catalyzed an efficient multicomponent one-pot synthesis of poly substituted pyridines

B. Janardhan, V. Ravibabu, Peter. A. Crooks and B. Rajitha

Department of Chemistry, National Institute of Technology, Warangal, AP, India

Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for

Medical Sciences, Little Rock, AR 72205 USA

Abstract: A series of poly substituted pyridines (3,11-disubstituted-7-aryl-5,6,8,9-tetrahydro-dibenzo[c,h]acridines) were synthesized by the multicomponent condensation of 6-substituted-1-tetralone, aromatic aldehydes and ammonium acetate in ethanol using L-proline as an efficient organocatalyst. This methodology is mild, efficient, high yielding and the catalyst is inexpensive, easily recovered from the reaction mixture and reused for five times without losing its activity.

Keywords: Multicomponent condensation; poly substituted pyridines; L-proline; 6-substituted-1-tetralone.