Iodine-catalyzed addition of 2-mercaptoethanol to chalcone derivatives: Synthesis of the novel β-mercapto carbonyl compounds
Gürkan Yerli, Hayreddin Gezegen and Mustafa Ceylan
Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpasa University, 60250 Tokat, Turkiye.
Abstract: In this study, a series of novel β-mercapto carbonyl derivatives (3-(2-hydroxyethylthio)-1,3-diarylpropan-1-one) (5a-i) were prepared by addition of 2-mercaptoethanol (4) to chalcones (3a-i) in the presence of catalytic amount of iodine (10 mol %) in CH 2Cl 2.
Keywords: Chalcone; 2-mercaptoethanol; iodine; Thia- michael addition; β-mercapto carbonyl. |