16.

Concise synthesis of a novel antifungal agent 4-methoxydecanoic acid

Pagudala Narsimha and Akkirala Venkat Narsaiah

Organic and Biomolecular Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, INDIA

Abstract: 4-Methoxy decanoic acid is belongs to a fatty acid family and has a novel anti- fungal activity. The aliphatic molecule has been synthesized in seven steps with an overall yield 41%. The synthesis was started from a commercially available epichloro hydrin and all the reactions were very clean.

Keywords: Epichlorohydrin; Grignard reaction; methyliodide; oxidation; hydrolysis. © 2013 ACG Publications. All rights reserved.