Synthesis and antifungal evaluation of imines derived from 3-Amino-2-isopropyl-3H-quinazolin-4-one
Idris Karakaya, Semistan Karabuga, Zeynep Ulukanli, and Sabri Ulukanli
Department of Chemistry, Faculty of Science and Letters, Osmaniye Korkut Ata University, Karacaoglan Campus, 80000 Osmaniye/Türkiye
Department of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum/Türkiye
Department of Chemistry, Faculty of Science and Letters, Kahramanmaras Sutcu Imam University, 46100 Kahramanmaras/Türkiye
Department of Biology, Faculty of Science and Letters, Osmaniye Korkut Ata University, Karacaoglan Campus, 80000 Osmaniye/Türkiye
Abstract: Novel Schiff bases were synthesised using 3-aminoquinazolinone (1) and a variety of aldehydes in the presence of acetic acid as solvent. Antifungal evaluation of the compounds was carried out by the agar dilution method. Among the all compounds prepared, quinazolinone itself showed the best fungiostatic activity against all filamentous fungi.
Keywords: Quinazolinone; schiff bases; Imines; antifungal; antimicrobial. © 2013 ACG Publications. All rights reserved. |