6.

Mg(OMe) 2 as a versatile catalyst for one-pot synthesis of 6-aryl-5-cyano-2-(oxo / thio) uracil derivatives and their antimicrobial evaluations

Yellajyosula L N Murthy, Rama Mohana Rao Saviri, Atchuta Ramaiah Parimi and Saranapu Nareesh

Organic Research Labs, Department of Organic Chemistry, Andhra University, Visakhapatnam, 530 003, India

Abstract: A series of substituted 6-aryl 5-cyano 2-uracil and 6-aryl 5-cyano 2-thiouracils (1a-1l) were achieved by the reaction of various aldehydes, ureas, thioureas and ethylcyanoacetate using Magnesium methoxide as a versatile catalyst. All compounds were screened for antibacterial and antifungal activities against 6 strains Bacillus substilis , Streptococcus sp, Pseudomas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus nigermicroorganisms using Muller-Hinton broth method. Some of the prepared compounds exhibited promising activities when compared to the standard Linezolid & Amphotercine-B.

Keywords: Magnesium methoxide; oxo/thio uracil derivatives; antimicrobial activity; methodology.