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Synthesis and antimicrobial activity of some novel fused heterocyclic moieties

Nareshvarma Seelam, Satya P. Shrivastava and Somarouthu Prasanthi

Department of Chemistry, K. L. University, Vaddeswaram, Guntur, A.P, India-522502

Heterocyclic Research laboratory, Department of Chemistry, Dr. H.S. Gour. Central University, Sagar, M.P, India-470003

Abstract: Since the discovery of heterocyclic moieties the chemistry of 1,3,4-thiadiazole and their fused compounds continue to draw attention of organic chemists due to their various biological activities. Here a new class of 1, 3, 4-thiadiazoles which are incorporating with isoxazolo-thiazole moieties were synthesized by the reaction of chalcone derivatives of [ 1, 3, 4 ] thiadiazol-2-yl)-thiazolidin-4-one with hydroxylamine hydrochloride. The chemical structures of these compounds were confirmed by IR, NMR ( 1H & 13C) and mass spectral studies. The new synthesized compounds were evaluated for their antimicrobial activity. The final results revealed that some of the compounds were exhibited well antimicrobial activity compared to the standard drugs.

Keywords: Thiadiazole; pyrazole; thiazolidinones; antimicrobial studies; anti-tuberculosis studies.