A Simple and efficient protocol for the synthesis of 1,4-dihydro pyridines (Hantzsch pyridines) catalyzed by Germanium (IV) iodide
Chandramouleswararao Jillepalli, Praveen Kumar Bonkuri and Madhukar Jeripothula
Department of Chemistry, Kakatiya University, Warangal, Telangana-506009, India
Abstract: A simple and efficient protocol has been developed for the synthesis of Hantzsch pyridines. In the reported synthesis, a variety of aldehydes undergo smooth condensation reaction with ethyl acetoacetate and ammonium acetate in presence of Germanium (IV) iodide in acetonitrile. This method is applicable to a variety of substrates to afford the corresponding 1,4-dihydropyridines in one-pot reaction in excellent yields.
Keywords: Aldehydes; diketones; ammonium acetate; GeI 4; 1,4-Dihydropyridine. © 2014 ACG Publications. All rights reserved. |