Stereoselective synthesis of tuberculostatic agent (S,S)-ethambutol
J. Kranthi Kumar and A. Venkat Narsaiah
Organic and Biomolecular Chemistry Division, Indian Institute of Chemical Technology, Hyderabad-500007, INDIA
Abstract: A simple and efficient asymmetric synthesis of (S,S)-Ethambutol has been carried out using a chiral butanediol. The synthesis was completed within six steps with an overall yield 53% and the enantiomeric purity of final product was 98%. All the reactions were very clean and the yields are excellent.
Keywords: Ethambutol; butanediol; protection; tuberculosis; oxalylchloride; reduction. © 2014 ACG Publications. All rights reserved. |