Eco-friendly synthesis of novel indeno-pyrazole derivatives and their in-vitro antimicrobial screening
Ashok P. Acharya, Rahul D. Kamble, Shrikant V. Hese, Shuddhodan N. Kadam, Rajesh N. Gacche and Bhaskar S. Dawane
Organic Research Laboratory, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded (MS) India. 431606
School of Life Sciences, Swami RamanandTeerthMarathwada University, Nanded (MS) India. 431606
Abstract: In the present communication a series of novel indeno-pyrazole derivatives were synthesized by the reaction of α, β-unsaturated ketones with phenyl hydrazine in polyethylene glycol-400 (PEG-400) and few drop of acetic acid. The newly synthesized compounds were characterized and confirmed by IR, 1H-NMR, 13C-NMR and mass spectral data. The results obtained indicate the significance of indeno-pyrazole derivatives as potent scaffold for designing novel and broad spectrum antimicrobials.
Keywords: Indeno -Pyrazole derivatives, bleaching earth clay (pH12.5), Polyethylene glycol-400(PEG-400), Antimicrobial activity. © 2014 ACG Publications. All rights reserved. |