Synthesis and Bioevaluation of Some Phenolic Diarylpropanes as Anti-Cancer Agents
Kshama Kundu, Mrityunjay Tyagi, Birija S. Patro, Subrata Chattopadhyay and Sandip K. Nayak
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
Abstract: A convenient synthesis of six phenolic diarylpropanes has been formulated. A CuBr 2-catalyzed regioselective reaction was the key step for bromination of the arylpropanes. All the compounds showed good cytotoxicity to the human lung cancer A549 cell line. However, only one of these compounds induced apoptosis and a G1 cell cycle arrest by augmenting cellular ROS status. Introduction of bromo-substitution at the aryl groups increased the cytotoxicity significantly, but that was mainly due to necrosis.
Keywords: Anti-cancer activity; apoptosis; CuBr 2-induced bromination; reactive oxygen species. © 2014 ACG Publications. All rights reserved.
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