Synthesis, characterization and antimicrobial activities of amide derivatives of febuxostat intermediate
Sreedhar Badvel, Veera Reddy Tummaluru, Venugopal Reddy Katta, Vidya Sagar Reddy Gandi, Naga Raju Chamarthi and Padmavathi Venkatapuram
Department of Chemistry, Vikrama Simhapuri University, Nellore-524 003, India.
Department of Biotechnology, Vikrama Simhapuri University, Nellore-524 003, India.
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India .
Abstract: A series of new carboxamide derivatives of 3-(4-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)phenoxy)propionic acid were synthesized by Schotten-Baumann reaction. The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. The target molecules were evaluated for their efficacy as antimicrobial agents in vitro by disc diffusion method. Compounds 4c, 4f, 4g and 4i showed high inhibitory activity.
Keywords: Febuxostat intermediate; carboxamide derivatives; antimicrobial activity. © 2014 ACG Publications. All rights reserved. |