Stereoselective synthesis of C1-C24 fragment of antanapeptin-A

Srinivas Avula, Sunitha Malladi and Rajesh Kumar Gaddam

Department of Chemistry, Vaagdevi Degree & PG College, Kishanpura, Warangal, Telangana, India 506001

Abstract: The stereoselective synthesis of the (C1-C24) fragment of Antanapeptin–A is described. The required stereochemistry of b -hydroxy- a -methyl acid unit was accomplished through Aldol reaction using Evans’ chiral auxiliary followed by the installation of terminal alkyne with Ohira–Bestmann reagent.

Keywords: Antanapeptin A; Aldol Reaction; Stereo selective synthesis; Peptide; Evans’ auxiliary. © 2016 ACG Publications. All rights reserved.