Synthesis, spectral characterization and biological activity of N-4-(N-2-(trifluoromethylphenyl))sulfamoyl amide derivatives

Mavallur Varalakshmi and Chamarthi Nagaraju

Sri Venkateswara College of Engineering and Technology, Chittoor-517127, Andhra Pradesh, India

Department of Chemistry, Sri Venkateswara University, Tirupati-517001, Andhra Pradesh, India

Abstract: Synthesis of a series of new N -4-(N-2-(trifluoromethylphenyl))sulfamoyl amide derivatives 6(a-i) was accomplished by a sequence of reactions by using aniline as a starting compound (1). The newly synthesized compounds were characterized by the spectral analysis and evaluated their antibacterial activity. 5-Nitro-N-(4-(N-(2-(trifluoromethyl)phenyl)sulfamoyl)phenyl)furan-2-carboxamide (6b) exhibited the highest activity.

Keywords : Aniline; trifluoroacetic anhydride; sulfonylchloride; antibacterial activity. © 2016 ACG Publications. All rights reserved.