Synthesis, cytotoxic and antibacterial activities of 6-bromobenzo[d]thiazol-2(3H)-one-[1,2,3] triazole hybrids

Vasudeva Reddy Nagavelli, Sirassu Narsimha, Kumara Swamy Battula, Lavudya Sudhakar and Ranjith Kumar Thatipamula

Department of Chemistry, Kakatiya University, Warangal-506 009, Telangana,, India

Abstract: A series of new 6-bromobenzo[d]thiazol-2(3H)-one derived 1,2,3-triazole derivatives (3a-j) have been synthesized by 1,3-dipolar cycloaddition of 6-bromobenzo[d]thiazol-2(3H)-one (2) with propargyl bromide and different aryl azides in a copper catalyzed one-pot reaction. All the synthesized compounds (3a-j) were evaluated for their in vitro cytotoxic activity against two human cancer cell lines MCF-7 and HeLa. The results showed that these compounds showed good cytotoxicity against the tested cell lines as compared with that of standard drug Cisplatin. The antibacterial activity of the newly synthesized triazole derivatives (3a-j) were also studied against different bacteria. The activity results showed that majority of compounds showed good to moderate antibacterial activity compared with positive control drug Streptomycin.

Keywords: 6-bromobenzo[d]thiazol-2(3H)-one; 1, 2, 3-Triazole; Cytotoxicity; Antibacterial activity. © 2016 ACG Publications. All rights reserved.