Synthesis and cytotoxic activities of novel 2-(1,5-bis(aryl) penta-1,4-dien-2-yl) benzo[d]thiazol derivatives

Betül Şahin, Ayşe Şahin Yağlıoğlu and Mustafa Ceylan

Department of Chemistry, Faculty of Art and Science, Gaziosmanpasa Univesity, 60250, Tokat, Türkiye,

Department of Chemistry, Faculty of Science, Çankırı Karatekin University, 18100 Çankırı, Türkiye

Abstract: Novel 2-(1,5-bis(aryl)penta-1,4-dien-2-yl)benzo[d]thiazol (5a,b) and 2-(((1S,2S,E)-2-(benzo[d]thiazol-2-yl)-1,5-di-arylpent-4-en-1-yl)thio)aniline (6a,b) derivatives were obtained by addition of 2-aminobenzothiol to bis-benzylidinecyclobutanones (3a,b). The structures of the obtained compounds were characterized using the spectroscopic methods (NMR, IR, Elemental Analysis). Compounds 5a,b showed cytotoxic activities against C6 (Rat Brain tumor cells) and HeLa (human uterus carcinoma) in vitro. ©2016 ACG Publications. All rights reserved.

Keywords: 2-Alkylbenzothiazol; Anticancer; C6 and HeLa cell lines.