Organic Communications

ARTICLE in PRESS

 

  ARTICLE

Synthesis and biological activities of some new spiro 1,2,4-triazole derivatives having sulfonamide moiety

Hany M. Dalloul, Khaled El-nwairy, Ali Z. Shorafa and Ahmed Abu Samaha

Department of Chemistry, Faculty of Applied Science, Alaqsa University of Gaza, P.O.Box 4051, Gaza 76888, Palestine

Ministry of Education & Higher Education, Beirut Street, Southern Reemal, Gaza 76888, Palestine

Department of Biology, Faculty of Applied Science, Alaqsa University of Gaza, P.O.Box 4051, Gaza 76888, Palestine

Abstract: A new series of spiro 1,2,4-triazoles 5-9a-j were prepared by the reaction of appropriate amidrazones 4 with cyclic ketones in catalytic amount of p-toluene sulfonic acid. The structures of the titled compounds have been elucidated by the elemental analysis and spectroscopic data (IR, 1H NMR, 13C NMR and MS). The biological activities of the prepared compounds were investigated using well-established methods from the literature.

Keywords : Amidrazone; nitrilimines; spiro 1,2,4-triazole; sulfonamide; cyclic ketone. ©2017 ACG Publications. All rights reserved.