Cellulose-SO3H catalyzed synthesis of bis(α-aminophosphonates) and their antioxidant activity
Nemallapudi Bakthavatchala Reddy, Chereddy Syama Sundar, Balam Satheesh Krishna, Sarva Santhisudha, Poola Sreelakshmi, Sandip Kumar Nayak and Cirandur Suresh Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati - 517 502, India
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
Abstract: A simple and efficient synthesis of bis(α-aminophosphonates) has been developed by the reaction of aromatic aldehydes, 1,4-phenylenediamine and diethylphosphite in the presence of cellulose-SO 3H as catalyst under neat conditions at room temperature for 10-30 minutes. The synthesized compounds were screened for their antioxidant activity against DPPH, NO and H 2O 2 scavenging methods. All the compounds exhibited good to moderate activity.
Keywords : Bis(α-aminophosphonates); 1,4-phenylenediamine; diethylphosphite; cellulose-SO 3H; antioxidant activity. © 2017 ACG Publications. All rights reserved.