One-pot and multi-step syntheses of new 2-(4,5-dihydro-1H-pyrazol-1-yl) thiazole derivatives

Mehmet Gümüş, Ali Dişli, Mehmet Yakan, Serhat Yiğitcan and İrfan Koca 

Department of Chemistry, Faculty of Art & Sciences, Bozok University, Yozgat, Türkiye

Akdağmadeni Health College, Bozok University, Yozgat, Türkiye

Department of Chemistry, Faculty of Science, Gazi University, Ankara, Türkiye

Abstract: β-Ketoester and ethanone derivatives, potentially functional molecules, containing the pyrazole/thiazole scaffolds were synthesized. The structures of the synthesized novel compounds were confirmed by FTIR, 1H NMR and 13C NMR spectroscopy and elemental analysis. The NMR spectra of the synthesized compounds are analyzed. Furthermore, ABX systems in pyrazole ring were studied in detail and the coupling constants of the diastereotopic protons.

Keywords: Pyrazole;, thiazole; β-ketoester, ethanone; diastereotopic protons. ©2018 ACG Publication. All right reserved.