4.

Secondary Metabolites Isolated from Iris germanica

Syeda F. Asghar, Shahid Aziz, Habib-ur-Rehman, Ishtiaq Ahmed, Hidayat Hussain, Atta-ur-Rahman and Muhammad I. Choudhary

Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad-13100, Pakistan

Department of Chemistry, University of Paderborn, Warburger Straße 100, 33098 Paderborn, Germany

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

Abstract: Phytochemical investigations of methanol extract of rhizome of Iris germanica L. resulted in the isolation of one new compound, 6,6-ditetradecyl-6,7-dihydrooxepin-2(3H)-one (1) and five known compounds, 1-(2-(6′-hydroxy-2′-methylcyclohex-1′-enyloxy)-5-methoxyphenyl)ethanone (2) 4-hydroxy-3-methoxyacetophenone (3), irisolone (4) irisolidone (5) and 2-acetoxy-3,6-dimethoxy-1,4-benzoquinone (6) .The structures of the compounds were determined on the basis of spectroscopic techniques. The antifungal activity of different soluble portions was measured. The hexane soluble portion of the methanol extract showed significant antifungal activity where as the ethyl acetate and chloroform soluble portions showed moderate activity. The methanol extract showed no antifungal activity.

Keywords: Iris germanica ; Iridaceae; secondary metabolite; antifungal activity.