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Free-radical Scavenging Flavonol 3-O-glycosides from the Leaves of Ribes biebersteinii Berl.
Abbas Delazar, Samira Lasheni, Fatemeh Fathi-Azad, Lutfun Nahar, Md. Mukhlesur Rahman, Solmaz Asnaashari, Mahdi Mojarab and Satyajit D. Sarker
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Drug Discovery and Design Research Division, Department of Pharmacy, School of Applied Sciences, Wolverhampton University, MA Building, Wulfruna Street,
Wolverhampton WV1 1LY, West Midland, UK
The School of Pharmacy, University of London, 29-39 Brunswick Square,
London WC1N 1AX, UK
Department of Pharmacy, School of Applied Sciences, Wolverhampton University, MM Building, Molineux Street, Wolverhampton WV1 1SB, West Midland, UK
Abstract: Ribes biebersteinii Berl. (Grossulariaceae), commonly known as ‘reddish-black berry’, is an Iranian medicinal plant found mainly in the region of the Arasbaran forests in Iran. Reversed-phase preparative HPLC analyses of the methanol extract of the leaves of this plant afforded four flavonol glycosides, e.g. quercetin 3-O-sophoroside (1), quercetin 3-O-sambubioside (2), kaempferol 3-O-sophoroside (3) and kaempferol 3,5-di-O-b-D-glucopyranoside (4). The free-radical-scavenging properties of the n-hexane, DCM and MeOH extracts, as well as the isolated compounds 1-4 were evaluated by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay.
Keywords: Ribes biebersteinii Berl.; Grossulariaceae; free-radical scavenging activity; flavonol glycosides; DPPH |