Three New 2-pyranone Derivatives from Mangrove Endophytic Actinomycete Strain Nocardiopsis sp. A00203
Cheng Lin, Chunhua Lu and Yuemao Shen
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering; Xiamen Engineering Research Center of Marine Microbial Drug Discovery; Fujian Engineering Laboratory of Pharmaceuticals; School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, P. R. China
Abstract: Three new 2-pyranone derivatives, namely Norcardiatones A (1), B (2) and C (3), were isolated from the agar cultures of the strain Nocardiopsis sp. A00203, a mangrove endophytic actinomycete. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HR Q-TOF-MS. Compound 1 showed week cytotoxicity against HeLa cells in MTT assay.
Keywords: 2-pyranone derivatives; Nocardiopsis sp. A00203; spectroscopic analyses. |