8.

Chemical Constituents and Antimicrobial Activity of Salix subserrata

Hidayat Hussain, Amira Badawy, Assem Elshazly, Afaf Elsayed, Karsten Krohn, Muhammad Riaz and Barbara Schulz

Department of Chemistry, Universität Paderborn, Warburger Straße 100, 33098 Paderborn, Germany

Department of Pharmacognosy, Faculty of Pharmacy,University of Zagazig, Zagazig, Egypt

NUST Center of Virolog and Immunology, National University of Science and Technology, H-12, Islamabad, Pakistan

Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 31806 Braunschweig, Germany

Abstract: The leaf and bark extracts of Salix subserrata showed promising antibacterial, antifungal, and antialgal activities. The bio-guided study of the chemical constituents of the bark and leaves of Salixsubserrata (Salicaceae) has resulted in the isolation and characterization of eight compounds. These six compounds were identified as (+) catechin ( 1), 1,2-benzenedicarboxylic acid, bis (2-ethylhexyl) ester ( 2), saligenin (3), methyl 1-hydroxy-6-oxocyclohex-2-enecarboxylate (4), catechol (5), propyl acetate ( 6), β-sitosterol (7), and β-sitosterol glucopyranoside ( 8), were isolated for the first time from Salixsubserrata. The above compounds were individually identified by spectroscopic analyses and comparisons with reported data . Preliminary studies indicated that compound 1, mixture of compounds 3/4, and 7 showed good antibacterial, fungicidal, and algicidal properties.

Keywords: Salixsubserrata; antimicrobial activity; Salicaceae; steroid .