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Ent -Kaurane Diterpenoids from Euphorbia hirta

Shijun Yan, Dawei Ye, Yi Wang, Yan Zhao, Jianxin Pu, Xue Du, Lei Luo and Yong Zhao

Maseno University, Chemistry Department, P. O. Box 333, Maseno, Kenya

College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, Yunnan, 650500, P. R. China

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650204, P. R. China

Abstract: A new ent- kaurane diterpenoid was isolated from the ethanol extract of Euphorbia hirta, and elucidated as 2β,16α,19 -trihydroxy-ent-kaurane (1), along with two known ent - kauranes, 2β,16α -dihydroxy-ent-kaurane (2) and 16α,19 -dihydroxy-ent-kaurane (3). Their structures were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and HRESIMS evidence.

Keywords: Euphorbiaceae; Euphorbia hirta; ent -kaurane; diterpenoid