2.

Rare 1,2’-binaphthyls Produced by Nodulisporium hinnuleum Smith (ATCC 36102)

Gerhard Schlingman, Scott Luckman, Leonard A. McDonald and Frank E. Koehn

Wyeth Research, Department of Biosynthetic Chemistry, 401 North Middletown Road, Pearl River, NY 10965, USA

Abstract: In the course of processing extracts from fermentations with Nodulisporium hinnuleum Smith (ATCC 36102) to obtain demethoxyvirdin, we noticed that this fungus produced several other secondary metabolites as well. In an effort to identify these components, four new, related natural products designated hinnulin A-D (1-4) were isolated and characterized. Structure elucidation of the hinnulins, primarily by NMR spectroscopy, revealed that these belong to the rare class of 1,2’-binaphthyl natural products.

Keywords: Nodulisporium hinnuleum; binaphthyl; fungal metabolite; oxygen reactive compounds.