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Phytochemical Investigation of Leontice leontopetalum L. subsp. ewersmannii with Antioxidant and Anticholinesterase Activities

Ufuk Kolak, Işıl Hacıbekiroğlu, Mehmet Boğa, Fevzi Özgökçe, Murat Ünal, M.Iqbal Choudhary and Ayhan Ulubelen

Department of General and Analytical Chemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Türkiye

Department of Chemistry, Faculty of Science and Letters,Batman University, 72060 Batman, Türkiye

Department of Biology, Faculty of Science and Letters,Yüzüncü Yıl University, 65080 Van, Türkiye

Department of Biology, Faculty of Education,Yüzüncü Yıl University, 65080 Van, Türkiye

H.E.J. Research Institute of Chemistry,University of Karachi, 72995 Karachi, Pakistan

Abstract: Two known quinolizidine alkaloids, lupanine and leontiformidine, were isolated from the tubers of L. leontopetalum subsp. ewersmannii. Lupanine having the highest inhibition of lipid peroxidation at 100 m g/mL among the tested samples indicated almost the same ABTS cation radical scavenging activity with BHT, a -tocopherol and (+)-catechin at the same concentration . Lupanine and the alkaloidal extract showed almost the same butyrylcholinesterase inhibitory activity with galantamine at 200 m g/mL.

Keywords: Leontice leontopetalum L. subsp. ewersmannii; Berberidaceae; lupanine; anticholinesterase.