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Phenolic Compounds and Terpenoids from Hypericum lanceolatum

Hippolyte K. Wabo, Théodora K. Kowa, Antoine Honoré N. Lonfouo, Alembert T. Tchinda, Pierre Tane, Haruhisa Kikuchi, Michel Frédérich and Yoshiteru Oshima

Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon

Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaounde, Cameroon

Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan

Laboratory of Pharmacognosy, Department of Pharmacy, CIRM, University of Liege, B36, 4000 Liege, Belgium

Abstract: A benzophenone, 2,2’,5,6’-tetrahydroxybenzophenone (1), and one xanthone, 5-hydroxy-3-methoxyxanthone (2), were newly described as natural products from the leaves and the stem barks of Hypericumlanceolatum, along with the known compounds friedelin (3), betulinic acid (4), allanxanthone A (5), 1,3,6-trihydroxyxanthone (6), isogarcinol (7), sitosterol 3-O- β -D-glucopyranoside (8), 1-hydroxy-6-methoxyxanthone (9), 6,7-dihydroxy-1,3-dimethoxyxanthone (10), 3-hydroxy-5-methoxyxanthone (11), 1,7-dihydroxy-3,6-dimethoxyxanthone (12) and calophyllumin A (13). Their structures were elucidated by spectroscopic means and comparison with published data.

Keywords: Hypericum lanceolatum ; Guttiferae; xanthones; benzophenones; terpenoids.