4.

Cytochalasin H2, a New Cytochalasin, Isolated from the Endophytic Fungus Xylaria sp. A23

Yu Li 1, Chunhua Lu, Yaojian Huang 2, Yaoyao Li and Yuemao Shen

School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250000, P. R. China

School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, P. R. China

Abstract: A new natural product, cytochalasin H2 (1), together with cytochalasin H (2) were obtained from the agar cultures of the strain Xylaria sp. A23, which was isolated from Annona squamosa. The chemical structures of them were elucidated by spectroscopic and mass spectrometric analyses, including 1D-, 2D-NMR and HR FTMS. Compound 1 showed week cytotoxicity against HeLa and 293T cell lines by MTT assay.

Keywords: Cytochalasin H2; cytochalasin H; spectroscopic analyses..