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Chemical Composition, Antioxidant and Anticholinesterase Activities of the Essential Oil of Salvia chrysophylla Staph

Mehmet Emin Duru, Gülsen Tel, Mehmet Öztürk and Mansur Harmandar

Faculty of Sciences, Department of Chemistry, Mugla University, 48121 Mugla, Türkiye

Abstract: The essential oil from the aerial parts of Salvia chrysophylla Staph (Lamiaceae), endemic to Turkey, was investigated by using GC and GC-MS. Fifty-four of 55 components, represented 99.52% of the total oil, were identified. The major components of the essential oil were found to be α-terpinenyl acetate (36.31%), β-caryophyllene (15.29%), linalool (8.12%) and β-elemene (4.26%). The antioxidant activity of the oil was investigated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-carotene/linoleic acid tests. Anticholinesterase activity was screened against acetylcholinesterase and butyrylcholinesterase which are the chief enzymes of Alzheimer’s disease. The essential oil showed weak antioxidant activity. However, at 1 mg/mL concentration, the essential oil exhibited mild acetylcholinesterase (52.5±2.0%) and moderate butyrylcholinesterase (76.5±2.7%) inhibitory activity.

Keywords: Salvia chrysophylla ; essential oil; GC and GC-MS; antioxidant activity; anticholinesterase activity