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Secondary Metabolites of Aspergillus sp. CM9a, an E ndophytic Fungus of Cephalotaxus mannii

Heng Xue, Chunhua Lu, Lanying Liang and Yuemao Shen

School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China

School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250 012 , China

Chinese Medicine Hospital of Yuncheng County, Yuncheng, Shandong, 274700, Chin

Abstract: Eleven compounds belonging to eight structure types, namely cyclopentenedione (1), diketopiperazines (2, 9, 10), lactone (3), benzophenone (4, 5), terpene (6), anthraquinone (7), diphenyl ethers (10), and alkaloid (11) were isolated from the cultivation extract of the strain Aspergillus sp. CM9a, which was isolated from the stems of Cephalotaxus mannii. Among them, compounds 1, 2, and 3 were determined to b e new ones on the basis of spectroscopic data including 1D- and 2D - NMR experiments and HR Q-TOF MS. The structures of the eight known compounds were characterized based on their NMR data and by comparison with those reported.

Keywords: Aspergillus sp. CM9a; diketopiperazine; anthraquinone ; Cephalotaxus mannii.