2.

A New Isoflavonolignan Glycoside from the Roots of Sophora tonkinensis

Ruiyun Yang, Yansu Lan, Zhongjing Huang, Changlun Shao, Hong Liang, Zhenfeng Chen and Jun Li

Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education, School of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004, China

School of Chemistry and Ecological Engineering, Guangxi University for Nationalities, Nanning 530006, China

School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

Key Laboratory of Ecology of Rare and Endangered Species and Environmental Conservation, Ministry of Education, College of Environment and Resources, Guangxi Normal University, Guilin 541004, China

Abstract: A new isoflavonolignan glycoside, butesuperin B-7''-O- b -glucopyranoside (1) along with a known isoflavonolignan butesuperin A (2), were isolated from the roots of Sophora tonkinensis. The structure of the new compound was elucidated using spectroscopic methods, mainly 1D and 2D NMR. Compound 1 showed week cytotoxicity against BEL-7404 and NCI-H460 cells in MTT assay.

Keywords: Sophora tonkinensis ; isoflavonolignan; butesuperin B-7''-O- b -glucopyranoside.