6.

Synthesis and Myocardial Ischemia Protective Effect of Ocotillol-Type Derivatives

Bi Yi, Wang Tian, Meng Qingguo, Zhang Jiangfen, Wang Liang, Li Qiang, Zhao Fenglan and Sun Haijun

Department of Medicinal Chemistry, School of Phamacy, Yantai University, 32 Qingquan Road, Yantai 264005, China

Department of pharmacology ， School of Phamacy, Yantai University, 32 Qingquan Road, Yantai 264005, China

Abstract: A series of ocotillol-type derivatives bearing a glycosyl moiety were synthesized. Among them, compound 3a and 3b led to a reduction in the increased CK, LDH, MDA activity and attenuate the decrease of SOD, GSH-PX and T-AOC compared with the iso group. In the heart section, compound 3a and 3b group showed nearly normal myofibrillar structure nearly without neutrophil granulocytes infiltration in the iso group. These results indicated that ocotillol-type derivatives may be the good lead compounds with protective property of myocardial ischemia.

Keywords: Ocotillol-type derivatives; myocardial ischemia; synthesis; ginsenoside.