13.

Jaspiferin A and B: Two New Secondary Metabolites from   the South China Sea Sponge Jaspis stellifera

Shengan Tang, Rong Xu, Wenhan Lin and Hongquan Duan

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmaceutical Sciences, Research Center of basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China

Department of Pharmacy, Quanzhou Medical College, Quanzhou, 362000, China

National Research Laboratories of Natural and Biomimetic drugs, Peking University, Beijing, 100083, China

Abstract: A chemical investigation of marine sponge Jaspis stellifera, collected from South China Sea, led to the isolation of two new compounds, Jaspiferin A and B (1-2), and six known compounds, gibepyrone F (3) , p- hydroxy benzaldehyde (4) , 3-Indole-3-aldehyde (5) , Thymine (6) , 24(28)-dehydroaplysterol (7) , (25s)-26- methylene-cholest-4-en-3-one (8). Their structures were determined by extensive spectroscopic analysis in association with physical and chemical properties, as well as comparison of their spectral data with these reported in literatures. The biogenetic transformation of compound 2 was also speculated.

Keywords: Jaspis stellifera ; marine sponge; chemical investigation.