22.

Melicimides A and B: Two New Ceramides from Stem Bark of Melicia excelsa

Hidayat Hussain, Awazi Tengu Nyongha, Etienne Dongo, Amin Badshah, Ivan R. Green and Wen Zhang

Department of Chemistry, Universität Paderborn, Warburger Straße 100, 33098 Paderborn, Germany

Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Sultanate of Oman

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P. O. Box 812, Yaounde, Cameroon

Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan

Department of Chemistry, University of Stellenbosch, P/Bag X 1, Stellenbosch,7600, South Africa

Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433 P. R. China

Abstract: Melicimides A (1) and B (2), two new ceremides have been isolated from Melicia excelsa ( Moraceae). The structures of the new compounds were determined by comprehensive analyses of their 1D ( 1H and 13C NMR), 2D NMR (including COSY, HMQC, and HMBC) and ESIMS spectral data. A known compound viz., β-sitosterol has also been identified.

Keywords: Moraceae ; Melicia excelsa; Ceramide; Structure elucidation.