5.

Constituents From the Stem Bark of Cinnamomum zeylanicum Welw. (Lauraceae) and Their Inhibitory Activity Toward Plasmodium falciparum Enoyl-ACP Reductase Enzyme

Eric René Sieliatchom Nkanwen, Maurice Ducret Awouafack, Jean Jules Kezetas Bankeu, Hippolyte Kamdem Wabo, Sufyan Awad Alkarim Mustafa, Muhammad Shaiq Ali, Marc Lamshöft, Muhammad Iqbal Choudhary, Michael Spiteller and Pierre Tane

Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon

International Center for Chemical and Biological Sciences, University of Karachi; Karachi 75270, Pakistan

Department of Chemistry, Faculty of Science, University of Bamenda, P.O. Box 39, Bambili, Cameroon

Medical Biochemistry Research Unit, Medicinal and Aromatic Plants Research Institute, National Center for Research, P.O. Box 2404, Khartoum, Sudan

Institut für Umweltforschung (INFU) der Fakultät Chemie, Lehrstuhl für Umweltchemie und Analytische Chemie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, D-44221 Dortmund, Germany

Abstract: A trans cinnamic anhydride (1) isolated for the first time from a natural source, along with the known compounds: ferrulic acid (2), (E) p-hydroxy cinnamic acid (3), clovanediol (4), squalene (5), and α -bisabolene (6) were isolated from the stem bark of Cinnamomum zeylanicum. Their structures were elucidated by interpretation of NMR and MS data, and by comparison of these data with those reported in the literature. Their inhibitory properties were evaluated against Plasmodium falciparum enoyl-ACP reductase (PfENR) enzyme. Compounds 1 , 5 and 6 showed moderate inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR) enzyme.