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A New Bezoxepine Derivative from Senecio desfontainei

Syed Hamid Hussain, Abdul Latif, Mohammad Arfan, Mumtaz Ali, Thomos J Simpson, Russell J Cox, Farzana Shaheen and Ghias Uddin

Department of Chemistry, Bacha Khan University, Charsadda, Pakistan

Department of Chemistry, University of Malakand, Chakdara Dir (L), Pakistan

Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan

School of Chemistry, University of Bristol, Bristol, United Kingdom

International Center for Chemical and Biological Sciences, University of Karachi, Pakistan

Abstract: Phytochemical investigation of the aerial parts of Senecio desfontainei afforded one new benzoxepin derivative, Senecioside (1) along with eleven known compounds (2-12). Their structures were assigned from 1H and 13C NMR spectra, DEPT and by 2D COSY, NOE, HSQC and HMBC experiments. All these compounds were tested for antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 2, 3, 4, 6 and 9 showed significant antioxidant activity against DPPH radicals.

Keywords: S enecio desfontainei ; Compositae; Senecioside; Antioxidant activity