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A New Apiofuranoside from the Rattan of Piper flaviflorum

Yu Wu, Fei Long, Chengjian Zheng, Qianliang Ming, Xuehong Deng, Jianyong Zhu and Luping Qin

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China ,

Department of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Huatuo Road, Fuzhou 350108, P. R. China,

Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai 200433, P. R. China

Abstract: A new apiofuranoside, named flavifloside A (1), together with two known hydroquinone diglycoside acyl ester, seguinoside E (2), seguinoside K (3) and a new natural product, 6'-O-(3, 4-dimethoxycinnamoyl)-arbutin (4), were isolated from the rattan of Piper flaviflorum. All these compounds were reported from this plant for the first time. Their structures were elucidated by detailed analyses of NMR, IR and MS data. In the mean time, all the compounds have been tested against A549, HCT116, MDA-MB-231 and CCRF-CEM cancer cell lines. Only flavifloside A showed moderate cytotoxicity against CCRF-CEM cancer cell line and none of them showed significant cytotoxicity against the other tested cell lines.

Keywords: Piper flaviflorum ; apiofuranoside; flavifloside A . © 2014 ACG Publications. All rights reserved.