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Pharmacologically Active C-19 Diterpenoid Alkaloids from the Aerial parts of Aconitum laeve Royle

Seema Begum, Mumtaz Ali, Abdul Latif, Waqar Ahmad, Sultan Alam, Muhammad Nisar, Muhammad Zeeshan, Mahmud Tareq Hassan Khan, Farzana Shaheen and Manzoor Ahmad

Department of Chemistry, Department of Botany & Department of Pharmacy, University of Malakand, Chakdara, Dir (L). Khyber Pakhtunkhwa, Pakistan

HEJ Resesrch Institute of Chemistry, ICCBS, University of Karachi, Karachi-75270

GenØk-Center for Biosafety FellesLab (GenØk), MH Building, IMB University of Tromsø 9037,Tromsø, Norway

Department of Chemistry, Norwegian University of Science and Technology (NTNU), N-7491, Trondheim, Norway

Abstract: Two new lycoctonine type C19-diterpenoid alkaloids, swatinine-A (1), and swatinine-B (2), along with four known C19-diterpenoid alkaloids, foresticine (3), neoline (4), delvestine (5), and chasmanine (6), were isolated from the aerial parts of the Aconitum laeve Royle. The structures of compounds 1 and 2 were deduced on the basis of spectroscopic techniques (EI-MS, HREI-MS, 1H NMR, 13C NMR, HMQC, and HMBC). Biological activities like inhibition of the multifunctional copper-containing enzyme tyrosinase, anti-oxidant and anti-inflammatory have also been carried out for all the compounds and reported herein. The structure-activity relationships for the inhibition of the enzyme tyrosinase by the compounds have been discussed.

Keywords: Aconitum laeve Royle; C19-diterpenoids alkaloids chemistry; swatinine-A; swatinine-B; antioxidant; anti-inflammatory; tyrosinase inhibitors. © 2014 ACG Publications. All rights reserved.