Isolation and Absolute Configuration of Boehmenan from Durio affinis Becc.
Rudiyansyah, Masriani, I. Wayan Mudianta and Mary J. Garson
Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Tanjungpura, Ahmad Yani Street, 78124 West Kalimantan, Indonesia
Department of Chemistry, Faculty of Education, University of Tanjungpura, Ahmad Yani Street, 78124 West Kalimantan, Indonesia
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
Abstract: Boehmenan (1) is a lignan which has two feruloyl moieties at C-9 and C-9"' respectively. The structural characterization of (+)-boehmenan was confirmed by 1H-NMR, 13C NMR and HRESIMS as well as by direct comparison with the literature. CD measurements established a 7S' , 8R' configuration. Cytotoxicity evaluation showed that boehmenan is moderately active against the T47D cell line with IC 50 13.7 m g/mL and shows weak activity against the HeLa cancer cell line with IC 50 93.5 m g/mL. Boehmenan is also non-cytotoxic to the Vero cell line. From this study, boehmenan X and erythro-carolignan E were also obtained.
Keywords: Bombacaceae; Boehmenan; Durio affinis; T47D cell . © 2014 ACG Publications. All rights reserved. |