1.

New Cyclolignans from Origanumglandulosum Active Against b -amyloid Aggregation

Abdelkader Basli, Jean-Claude Delaunay, Eric Pedrot, Stéphane Bernillon, Khodir Madani, Jean-Pierre Monti, Jean Michel Mérillon, Mohamed Chibane and Tristan Richard

GESVAB (EA 3675), ISVV, Université de Bordeaux 2, 33882 Villenave d’Ornon, France.

Université de Bejaia, Laboratoire 3BS, Béjaia, Algérie.

INRA - UMR 1332 BFP, Centre INRA de Bordeaux, Villenave d’Ornon, France.

Université AMO Bouira, Faculté des Sciences, Lab. de Technologie Alimentaire, Bouira, Algérie.

Abstract: Origanum glandulosum Desf is an endemic flavoring herb widely distributed in North Africa that is commonly used in traditional medicine. This oregano species is rich in essential oils but little is known about its phenolic composition. In the present study, a crude extract of O. glandulosum was prepared in order to isolate and investigate its neuroprotective potential to inhibit β-amyloid peptide (Aβ) aggregation. The three major compounds of the extract were isolated: rosmarinic acid and two cyclolignans in Origanum genus, globoidnan A and a new derivative named globoidnan B. Rosmarinic acid and globoidnan A showed significant anti-aggregative activity against β amyloid aggregation (IC50 7.0 and 12.0 µM, respectively). In contrast, globoidnan B was found to be less active.

Keywords: Origanum glandulosum ; oregano; cyclolignans; β-Amyloid aggregation; NMR. ©2014 ACG Publications. All rights reserved.