Untitled Document

Records of Natural Products

Year: 2014 Volume: 8 Issue: 3

SHORT REPORT

15.

Secondary Metabolites from Jacaranda Mimosifolia and Kigelia Africana (Bignoniaceae) and Their Anticandidal Activity

Lazare Sidjui Sidjui, Elisabeth Menkem Zeuko’o, Rufin Marie Kouipou Toghueo, Olivier Placide Noté, Valérie Mahiou-Leddet Gaëtan Herbette, Fabrice Boyom Fekam, Evelyne Ollivier and Gabriel Ngosong Folefoc

Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaoundé, Cameroon

Institute of Medical Research and Medicinal Plant Studies P.O Box 6163 Yaoundé, Cameroon

Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaoundé, Cameroon

Laboratory of Pharmacognosy and Ethnopharmacology, UMR-MD3, Faculty of Pharmacy, Aix-Marseille University, 27 Bd Jean Moulin, CS 30064, 13385, Marseille cedex 5, France .

Spectropole, FR1739, Aix-Marseille Université, Campus de St Jérôme - service 511, 13397 Marseille, cedex 20, France

Abstract: Fr om the stem barks of Jacaranda mimosifolia benzoic acid (1), 1-naphthaleneacetic acid, 5-carboxy-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a-trimethyl-[1S-(1α,2β,4aβ,8aα)] (2), betulinic acid (3), lupeol (4) and ursolic acid (5) were isolated. Similarly, lapachol (6), dehydro-α-lapachone (7), 2- acetylfuro-1, 4-naphthoquinone (8), p-coumaric acid (9), caffeic acid (10), nonacosanoic acid, 2-(4-hydroxyphenyl)ethyl ester (11), β-sitosterol (12), kigelinol (13), oleanolic acid (14), β-friedelinol (15), pomolic acid (16), and kojic acid (17) were isolated from the stem barks of Kigelia africana . All the isolated compounds were characterized by using spectroscopic methods especially 1D and 2D NMR and ESI mass spectrometry and comparison with literature data. To the best of our knowledge, compounds 1, 2, 3 and 5, and compounds 11, 14, 15 and 16 were isolated for the first time from Jacaranda mimosifolia and Kigelia africana, respectively. All these compounds were screened for anticandidal activity by agar diffusion method and microbroth dilution technique on four Candida albicans strains (ATCC L26, ATCC12C, ATCCP37039, and ATCCP37037). Among them, compounds 9, 10, and 17 exhibited the highest anticandidal activity that varied between the microbial species (MIC= 0.01 ± 0.00 − 0.03 ± 0.00 mg/mL) on C. albicans ATCC L26, ATCCP37037, ATCCP37039 and ATCC12C strains. Compound 17 was likely the most active against the four Candida albicans strains (MIC= 0.01 ± 0.00 − 0.02 ± 0.00 mg/mL).