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Two new sesquiterpenes from a kind of TCM Pieces, Curcumae Radix

Honghua Wu, Honghong Zheng, Yantong Xu, Peng Zhang, Gang Chen and Yan Zhu

Tianjin State Key Laboratory of Modern Chinese Medicine ; Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R.China

Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology & Medicine, 220 Dongting Road, TEDA, Tjianjin 300457, P.R.Chin a

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R.Chin a

Abstract: Phytochemical study on the ethanol extract of the Curcumae Radix pieces, authenticated as the radixes of Curcuma wenyujin Y.H. Chen et C. Ling, led to the isolation of two new sesquiterpen e s , (1R,4R,5S,7S)-curwenyujinone ( 1 ) and zedoalactone H (2) , along with five known sesquiterpenes , zedoalactone E (3) , zedoarolide B ( 4), gwei curculactone (5), curdionolide A (6), c urcumenone (7) and one diterpene compound, curcuminol D (8). Their structures were elucidated on the basic of extensive spectroscopic analysis and computational ECD simulations.

Keywords: Curcumae Radix ; (1R,4R,5S,7S)-curwenyujinone ; zedoalactone H ; sesquiterpenes . © 2014 ACG Publications. All rights reserved.